As in most zombie games, you represent a unique character with your own character traits, except in Run, Fight, or Die! you will also have your own individual board with zombies you alone will encounter. Zombies move closer to you every round. You run from location to location, searching for weapons and survivors in a frantic attempt to stay alive. Survivors may bring new skills to help you in your desperate fight for survival, or in some cases, new challenges to overcome. In either case, every survivor provides you victory points. The game ends either when one player finds five survivors and declares the last round, or when a player reaches the town line (and the total Followers in play meets a minimum), or if a player gets bitten and turns.